Alexandra Holden is among the regular faces seen on film and TV. Among her notable appearances include film roles in Drop Dead Gorgeous, as Mary Johnson, followed by Sugar & Spice as Fern Rogers. She became recognized by audiences in the small screen when she appeared as the girlfriend of Ross Gellar in the hit sitcom FRIENDS, in which she was seen in seven consecutive episodes.

Aside from FRIENDS, Alexandra Holden also appeared in Ally McBeal as the recurring character of Jane Wilco, Tru Crime, and Six Feet Under. She was also the lead female character in the Aerosmith video, Hole in My Soul.